Then, what is Spider-Man's greatest weakness?
5 Weakness: Ethyl Chloride
This is the big one. Ethyl chloride is essentially Spider-Man's Kryptonite and it renders anyone's spider powers null and void. This makes ethyl chloride extremely powerful against Spider-Man, but this chemical cocktail doesn't have nearly the same reputation as Superman's Kryptonite.
Additionally, what was venoms weakness? Venom's Weaknesses
The Venom symbiote has two major weaknesses - sound and fire. Loud noises cause the symbiote to writhe in pain. That's how Peter Parker originally freed himself of the symbiote. In both cases, however, these weaknesses tend to be diminished with each new generation of symbiote.
Secondly, does Spider-Man have any weaknesses?
Weaknesses. Unlike many superheroes, Spider-Man does not have a weakness he is automatically vulnerable to, but in recent years methods have been created to render him vulnerable.
Is Spider-Man weak to cold?
15 The Common Cold
Unless we're talking about Spider-Man. Despite having survived the irradiated bite of a mutant spider, Peter Parker's immune system is astonishingly weak. Spidey seems to have spots swirling around his head (comic book for being sick) every other issue.
