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What is the difference between magnesium Bisglycinate and magnesium glycinate?

Author

David Richardson

Updated on February 19, 2026

What is the difference between magnesium Bisglycinate and magnesium glycinate?

The "bis" in bisglycinate means "two." That means instead of one glycinate amino acid (like in magnesium glycinate) there are two glycine amino acids (magnesium bisglycinate). The amino acids absorb well in the intestine due to its fortified organic structure, and thus the magnesium comes with it.

Thereof, is magnesium Bisglycinate the same as Glycinate?

Magnesium Glycinate. Our other preferred magnesium supplement is called magnesium glycinate. Magnesium glycinate (also called magnesium bisglycinate) is well-tolerated and absorbed in the body. In this case, the magnesium is combined with an amino acid called glycine.

Likewise, which type of magnesium is best? Orally, magnesium citrate is the best absorbed form (but it's bonded to a big molecule so there is a smaller amount of magnesium by weight). Mg oxide is the most poorly absorbed form but has the highest Mg per weight, so actually you may get more elemental magnesium out of the same dose of Mg oxide vs.

Also, what is magnesium Bisglycinate used for?

Uses. This medication is a mineral supplement used to prevent and treat low amounts of magnesium in the blood. Some brands are also used to treat symptoms of too much stomach acid such as stomach upset, heartburn, and acid indigestion.

When should you take magnesium Bisglycinate?

The recommended dose is 320 mg for women and 420 mg for men per day, which means taking up to four capsules unless otherwise advised. If you take four capsules a day, take them two at a time twice a day with food, and together with a vitamin B complex supplement to improve absorption.

Which is better magnesium glycinate or Bisglycinate?

Magnesium Glycinate. Our other preferred magnesium supplement is called magnesium glycinate. Magnesium glycinate (also called magnesium bisglycinate) is well-tolerated and absorbed in the body. In this case, the magnesium is combined with an amino acid called glycine.

What is the best brand of magnesium glycinate?

  • B Life Extension Magnesium Caps.
  • B Metagenics Mag Glycinate.
  • B Doctor's Best Magnesium.
  • B- Pure Encapsulations Magnesium.
  • B- Jigsaw Health Magnesium.
  • C+ Bluebonnet Chelated Magnesium.
  • C Viva Labs Chelated Magnesium.
  • C- Good State Health Solutions Ionic Magnesium.

Which Magnesium is best for sleep and anxiety?

Glycine is another sleep-inducing amino acid. One form of supplemental magnesium is magnesium glycinate. This is one of the most absorbable forms of magnesium you can take. Studies have shown that glycine improves sleep quality and promotes natural, healthy sleep patterns, including healthy REM cycles.

What is the most absorbable form of magnesium?

Magnesium citrate
Magnesium citrate is one of the most common magnesium formulations and can be easily purchased online or in stores worldwide. Some research suggests that this type is among the most bioavailable forms of magnesium, meaning that it's more easily absorbed in your digestive tract than other forms ( 4 ).

Is magnesium Glycinate the same as chelated magnesium?

Magnesium Glycinate and Magnesium Amino Acid Chelate
Magnesium amino acid chelate is usually bonded to a variety of amino acids, which are all larger molecules. In this form there is less magnesium by weight but the individual amino acids could all be beneficial for different things.

Does magnesium Glycinate help anxiety?

Magnesium glycinate has shown potential in combatting anxiety , as magnesium is known to assist with producing the hormone serotonin7 in your brain, which may significantly affect feelings of anxiety and happiness. 8 In fact, low magnesium intake was shown to decrease serotonin levels9 which can negatively affect mood.

Does magnesium Glycinate help you poop?

Often used for improving digestion and preventing constipation as it may cause loose stools or act as a natural laxative. Magnesium Glycinate — the best-absorbed form of magnesium, and gentle on the stomach. Less likely to cause laxative effects.

Which Magnesium is best for anxiety?

Which magnesium is best for anxiety?
  • Magnesium glycinate. Often used to reduce muscle pain.
  • Magnesium oxide. Commonly used to treat migraines and constipation.
  • Magnesium citrate. Easily absorbed by the body and also used to treat constipation.
  • Magnesium chloride.
  • Magnesium sulfate (Epsom salt).
  • Magnesium lactate.

Is magnesium Bisglycinate good for you?

Magnesium bisglycinate is the only magnesium shown to cross the blood brain barrier which makes it an excellent choice for aiding those with depression and/or anxiety, or migraine headaches. Stress of all types including chemical, emotional, hormonal or physical stress depletes magnesium from the body.

What form of magnesium is best to take?

Magnesium citrate
With excellent bioavailability—that is, the efficacy with which a substance is absorbed and used by the body—it's no wonder magnesium citrate one of the most highly recommended magnesium supplements by health professionals.

What are the symptoms of low magnesium in the body?

7 Signs and Symptoms of Magnesium Deficiency
  • Magnesium deficiency, also known as hypomagnesemia, is an often overlooked health problem.
  • Muscle Twitches and Cramps.
  • Mental Disorders.
  • Osteoporosis.
  • Fatigue and Muscle Weakness.
  • High Blood Pressure.
  • Asthma.
  • Irregular Heartbeat.

What is the best magnesium for anxiety and depression?

Which magnesium is best for anxiety?
  • Magnesium glycinate. Often used to reduce muscle pain.
  • Magnesium oxide. Commonly used to treat migraines and constipation.
  • Magnesium citrate. Easily absorbed by the body and also used to treat constipation.
  • Magnesium chloride.
  • Magnesium sulfate (Epsom salt).
  • Magnesium lactate.

What medications should you not take with magnesium?

Taking magnesium with these medications might cause blood pressure to go too low. Some of these medications include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.

Is it better to take magnesium in the morning or at night?

Therefore, magnesium supplements can be taken at any time of the day, as long as you're able to take them consistently. For some, taking supplements first thing in the morning may be easiest, while others may find that taking them with dinner or just before bed works well for them.

What type of magnesium is best for high blood pressure?

Magnesium taurate may be the best form for managing high blood sugar and high blood pressure, though more studies are necessary.

Why is magnesium glycinate better?

Magnesium glycinate (also called magnesium bisglycinate) is well-tolerated and absorbed in the body. We may use magnesium glycinate to improve blood sugar levels or to help reduce overall inflammation in the body. This form of magnesium is less likely to have a laxative effect than magnesium citrate.

Should I take magnesium everyday?

Magnesium Is Safe and Widely Available. Magnesium is absolutely essential for good health. The recommended daily intake is 400–420 mg per day for men and 310–320 mg per day for women (48). You can get it from both food and supplements.

Is it safe to take magnesium daily?

When taken by mouth: Magnesium is LIKELY SAFE for most people when taken by mouth appropriately. Doses less than 350 mg daily are safe for most adults. In some people, magnesium might cause stomach upset, nausea, vomiting, diarrhea, and other side effects.

What is the best magnesium to take daily?

Recommended daily amounts
AgeMaleFemale
14–18 years (RDA)410 mg360 mg
19–30 years (RDA)400 mg310 mg
31–50 years (RDA)420 mg320 mg
51+ years (RDA)420 mg320 mg

Is magnesium Glycinate better than magnesium oxide?

So magnesium by weight is higher if it's bonded to an extremely small molecule (like oxygen in Mg oxide) than if it's bonded to a large molecule like glycine (in Mg glycinate) or an amino acid (in magnesium amino acid chelate). Citrate and sulphate molecules are somewhat in the middle for size.

How much magnesium Glycinate should I take for sleep?

In general, it is recommended that users begin with the lowest suggested dose, and gradually increase as needed. For general health, sleep, stress: 100-350 mg daily. Individual dosing will vary, and can vary widely depending on an individual's magnesium levels. Magnesium is generally well tolerated by healthy adults.

Does magnesium make you gain weight?

Magnesium is a mineral that has many jobs in the human body. One of those jobs is regulating blood glucose levels. Reduced magnesium in the body has been linked to insulin resistance that could lead to weight gain.

Does magnesium Glycinate interact with any medications?

Magnesium glycinate and other supplements might also interfere or interact with the following medicines: Bisphosphonates: These are used to treat osteoporosis. The body does not absorb these drugs well if people take them too close to taking supplements or medications that contain a high amount of magnesium.

Which Magnesium is best for muscle cramps?

Magnesium citrate may be the most effective type if you want to try a supplement. If you're magnesium deficient, there may be other benefits from increasing your intake of this nutrient. And other remedies are available for leg cramping that may help.

Is Magnesium good for anxiety?

While further studies are needed, there is research to suggest magnesium may help fight anxiety. More recently, a 2017 review that looked at 18 different studies found that magnesium did reduce anxiety. Research has found that magnesium may help with brain functions that reduce stress and anxiety.

Does magnesium Bisglycinate cross the blood brain barrier?

Magnesium bisglycinate is an essential mineral needed for more than 300 enzymatic reactions in the body. Magnesium bisglycinate is the only magnesium shown to cross the blood brain barrier which makes it an excellent choice for aiding those with depression and/or anxiety, or migraine headaches.

Does magnesium give you gas?

Common Side Effects of Magnesium Citrate
The most commonly reported side effects caused by magnesium citrate include: Stomach and intestinal issues like gas, diarrhea, nausea, vomiting, and stomach cramping. High levels of magnesium in your bloodstream.