Keeping this in consideration, who is Sam Winchester's best friend?
Castiel
Additionally, who has Sam Winchester slept with? Madison. Madison and Sam met in Heart. There was a clear attraction between the two as soon as they met, but it wasn't until they believed her clear of the werewolf curse that she and Sam slept together.
Similarly, it is asked, are Sam and Dean best friends in real life?
In real life, they are best friends and were each other's groomsmen. Jared (Sam) and Jensen (Dean) have both said that they were skeptical at first about 'playing themselves'. Jared and Jensen said in a convention they were worried when they were called to the writer's room for the episode, because they never are.
What's special about Sam Winchester?
Once he's been drinking demon blood (which, again, great idea), Sam has access to a weirdly wide range of demonic powers. These included but were not limited to: super strength, telekinesis, precognition, immunity to demon attacks, and the ability to exorcise and destroy demons.
